Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy

Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy

The node of Ranvier is the key element in saltatory conduction along myelinated axons, but its specific protein organization remains elusive in the human species. To shed light on nanoscale anatomy of the human node of Ranvier in health and disease, we assessed human nerve biopsies of patients with...

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Bibliographic Details
Main Authors: Luise Appeltshauser, Janis Linke, Hannah S. Heil, Christine Karus, Joachim Schenk, Katherina Hemmen, Claudia Sommer, Kathrin Doppler, Katrin G. Heinze
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
Super resolution microscopy
dSTORM
Deep learning
Nerve biopsies
Polyneuropathy
Node of Ranvier
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001535

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http://www.sciencedirect.com/science/article/pii/S0969996123001535

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