G3BP1 modulates SPOP to promote prostate tumorigenesis

G3BP1 modulates SPOP to promote prostate tumorigenesis

Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase activi...

Full description

Bibliographic Details
Main Authors: Chandrani Mukhopadhyay, Pengbo Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Molecular & Cellular Oncology
Subjects:
g3bp1
spop
prostate cancer
cul3
ubiquitin ligase
androgen receptor
Online Access:http://dx.doi.org/10.1080/23723556.2022.2030171

Internet

http://dx.doi.org/10.1080/23723556.2022.2030171

Similar Items