Microbiota-derived acetate enhances host antiviral response via NLRP3

Microbiota-derived acetate enhances host antiviral response via NLRP3

The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production following influenza infection in mice.

Bibliographic Details
Main Authors: Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang, Liping Zhao, Guangxun Meng
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36323-4

Internet

https://doi.org/10.1038/s41467-023-36323-4

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