An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity achieved by host targeting can be especially useful i...

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Bibliographic Details
Main Authors: Kathryn L. Roche, Stacy Remiszewski, Matthew J. Todd, John L. Kulp III, Liudi Tang, Alison V. Welsh, Ashley P. Barry, Chandrav De, William W. Reiley, Angela Wahl, J. Victor Garcia, Micah A. Luftig, Thomas Shenk, James R. Tonra, Eain A. Murphy, Lillian W. Chiang
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-06-01
Series:The Journal of Clinical Investigation
Subjects:
Infectious disease
Virology
Online Access:https://doi.org/10.1172/JCI158978

Internet

https://doi.org/10.1172/JCI158978

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