Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

Alkaline phosphatase (AP) activity is highly upregulated in plasma during liver diseases. Previously, we demonstrated that AP is able to detoxify lipopolysaccharide (LPS) by dephosphorylating its lipid A moiety. Because a role of gut-derived LPS in liver fibrogenesis has become evident, we now exami...

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Bibliographic Details
Main Authors: Marlies Schippers, Eduard Post, Ilse Eichhorn, Jitske Langeland, Leonie Beljaars, Madhu S. Malo, Richard A. Hodin, José Luis Millán, Yury Popov, Detlef Schuppan, Klaas Poelstra
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
lipopolysaccharide
lipid A
hepatic stellate cells
liver fibrosis
alkaline phosphatase
Online Access:https://www.mdpi.com/2073-4409/9/12/2708

Internet

https://www.mdpi.com/2073-4409/9/12/2708

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