RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

Abstract Background GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive oncogene and is different from the classic PML-RARA in terms of thera...

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Bibliographic Details
Main Authors: Wenzhe Yan, Ji Li, Yang Zhang, Yafei Yin, Zhao Cheng, Jiayi Wang, Guoyu Hu, Sufang Liu, Yewei Wang, Yunxiao Xu, Hongling Peng, Guangsen Zhang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
APL
GTF2I-RARA
RNF8
RARA
Proteasome inhibitor
Online Access:http://link.springer.com/article/10.1186/s12935-019-0803-4

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http://link.springer.com/article/10.1186/s12935-019-0803-4

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