Radiomics using computed tomography to predict CD73 expression and prognosis of colorectal cancer liver metastases

Radiomics using computed tomography to predict CD73 expression and prognosis of colorectal cancer liver metastases

Abstract Background Finding a noninvasive radiomic surrogate of tumor immune features could help identify patients more likely to respond to novel immune checkpoint inhibitors. Particularly, CD73 is an ectonucleotidase that catalyzes the breakdown of extracellular AMP into immunosuppressive adenosin...

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Bibliographic Details
Main Authors: Ralph Saber, David Henault, Nouredin Messaoudi, Rolando Rebolledo, Emmanuel Montagnon, Geneviève Soucy, John Stagg, An Tang, Simon Turcotte, Samuel Kadoury
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Cancer
Immune checkpoint
Adenosine pathway
CD73
Radiomic biomarker
Interpretable machine learning
Online Access:https://doi.org/10.1186/s12967-023-04175-7

Internet

https://doi.org/10.1186/s12967-023-04175-7

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