Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced Arthritis

Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced Arthritis

Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease, and Krüppel-like factor 2 (KLF2) regulates immune cell activation and function. Herein, we show that in our experiments 50% global deficiency of KLF2 significantly elevated arthritic inflammation and pathogenesis, osteocl...

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Bibliographic Details
Main Authors: Manjusri Das, Moonmoon Deb, Dipranjan Laha, Matthew Joseph, Suman Kanji, Reeva Aggarwal, O. Hans Iwenofu, Vincent J. Pompili, Wael Jarjour, Hiranmoy Das
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
rheumatoid arthritis
KLF2
inflammation
monocytes
osteoclasts
MMP9
conditional knockout mice
Online Access:https://www.mdpi.com/2073-4409/8/8/908

Internet

https://www.mdpi.com/2073-4409/8/8/908

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