Influence of PhoPQ and PmrAB two component system alternations on colistin resistance from non-mcr colistin resistant clinical E. Coli strains

Abstract Background The current understanding of acquired chromosomal colistin resistance mechanisms in Enterobacterales primarily involves the disruption of the upstream PmrAB and PhoPQ two-component system (TCS) control caused by mutations in the regulatory genes. Interestingly, previous studies h...

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Bibliographic Details
Main Authors: Ching-Hsun Wang, L. Kristopher Siu, Feng-Yee Chang, Yu-Kuo Tsai, Li-Yueh Huang, Jung-Chung Lin
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Microbiology
Subjects:
Online Access:https://doi.org/10.1186/s12866-024-03259-8