The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response

The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response

Summary: The long pentraxin 3 (PTX3) plays a critical role in inflammation, tissue repair, and wound healing. Here, we show that PTX3 regulates disease pathogenesis in cutaneous leishmaniasis (CL). PTX3 expression increases in skin lesions in patients and mice during CL, with higher expression corre...

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Bibliographic Details
Main Authors: Gaurav Gupta, Zhirong Mou, Ping Jia, Rohit Sharma, Romaniya Zayats, Sayonara M. Viana, Lianyu Shan, Aldina Barral, Viviane S. Boaventura, Thomas T. Murooka, Abdel Soussi-Gounni, Camila I. de Oliveira, Jude E. Uzonna
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
cutaneous leishmaniasis
pentraxin 3
PTX3
regulation of immunity
immunopathogenesis
resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720315023

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http://www.sciencedirect.com/science/article/pii/S2211124720315023

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