Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We in...
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1657 |
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| author | Heeyoung Kang Hyun Joo Shin Hyeong Seok An Zhen Jin Jong Youl Lee Jaewoong Lee Kyung Eun Kim Eun Ae Jeong Kyu Yeong Choi Catriona McLean Kun Ho Lee Soo Kyoung Kim Hae Ryong Lee Gu Seob Roh |
| author_facet | Heeyoung Kang Hyun Joo Shin Hyeong Seok An Zhen Jin Jong Youl Lee Jaewoong Lee Kyung Eun Kim Eun Ae Jeong Kyu Yeong Choi Catriona McLean Kun Ho Lee Soo Kyoung Kim Hae Ryong Lee Gu Seob Roh |
| author_sort | Heeyoung Kang |
| collection | DOAJ |
| description | Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress. |
| first_indexed | 2024-03-10T05:45:26Z |
| format | Article |
| id | doaj.art-aaf140224e9448f881a85a7c3a05ad81 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:26Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-aaf140224e9448f881a85a7c3a05ad812023-11-22T22:11:46ZengMDPI AGAntioxidants2076-39212021-10-011011165710.3390/antiox10111657Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s DiseaseHeeyoung Kang0Hyun Joo Shin1Hyeong Seok An2Zhen Jin3Jong Youl Lee4Jaewoong Lee5Kyung Eun Kim6Eun Ae Jeong7Kyu Yeong Choi8Catriona McLean9Kun Ho Lee10Soo Kyoung Kim11Hae Ryong Lee12Gu Seob Roh13Department of Neurology, College of Medicine, Gyeongsang National University Hospital, Gyeongsang National University, Jinju 52727, KoreaBio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaBio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaUniversity of Tennessee Health Science Center, Department of Anatomy and Neurobiology, Memphis, TN 38163, USABio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaBio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaBio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaBio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaGwangju Alzheimer’s & Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, KoreaDepartment of Pathology, The Alfred Hospital, Melbourne 3004, AustraliaGwangju Alzheimer’s & Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, KoreaDepartment of Internal Medicine, College of Medicine, Gyeongsang National University Hospital, Gyeongsang National University, Jinju 52727, KoreaElectronics and Telecommunications Research Institute, Daejeon 34129, KoreaBio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, KoreaLipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress.https://www.mdpi.com/2076-3921/10/11/1657lipocalin-2amyloid-betaneuroinflammationiron accumulationoxidative stressblood–brain barrier leakage |
| spellingShingle | Heeyoung Kang Hyun Joo Shin Hyeong Seok An Zhen Jin Jong Youl Lee Jaewoong Lee Kyung Eun Kim Eun Ae Jeong Kyu Yeong Choi Catriona McLean Kun Ho Lee Soo Kyoung Kim Hae Ryong Lee Gu Seob Roh Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease Antioxidants lipocalin-2 amyloid-beta neuroinflammation iron accumulation oxidative stress blood–brain barrier leakage |
| title | Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_full | Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_fullStr | Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_full_unstemmed | Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_short | Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_sort | role of lipocalin 2 in amyloid beta oligomer induced mouse model of alzheimer s disease |
| topic | lipocalin-2 amyloid-beta neuroinflammation iron accumulation oxidative stress blood–brain barrier leakage |
| url | https://www.mdpi.com/2076-3921/10/11/1657 |
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