Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin

Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin

Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced thrombocytopenia (RIT and CIT, respectively). In th...

Full description

Bibliographic Details
Main Authors: Long Wang, Ting Zhang, Sha Liu, Qi Mo, Nan Jiang, Qi Chen, Jing Yang, Yun-Wei Han, Jian-Ping Chen, Fei-Hong Huang, Hua Li, Jie Zhou, Jie-Si Luo, Jian-Ming Wu
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Machine learning
Ingenol
Megakaryocyte differentiation
Thrombocytopenia
Platelets
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182200041X

Internet

http://www.sciencedirect.com/science/article/pii/S104366182200041X

Similar Items