Acute myeloid leukemia: from NGS, through scRNA-seq, to CAR-T. dissect cancer heterogeneity and tailor the treatment

Acute myeloid leukemia: from NGS, through scRNA-seq, to CAR-T. dissect cancer heterogeneity and tailor the treatment

Abstract Acute myeloid leukemia (AML) is a malignant blood cancer with marked cellular heterogeneity due to altered maturation and differentiation of myeloid blasts, the possible causes of which are transcriptional or epigenetic alterations, impaired apoptosis, and excessive cell proliferation. This...

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Bibliographic Details
Main Authors: Edoardo Peroni, Maria Luigia Randi, Antonio Rosato, Stefano Cagnin
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Acute myeloid leukaemia (AML)
Next generation sequencing (NGS)
Single cell sequencing (scRNA-seq)
Intratumoral heterogeneity
Therapeutic targets
Personalized medicine
Online Access:https://doi.org/10.1186/s13046-023-02841-8

Internet

https://doi.org/10.1186/s13046-023-02841-8

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