A novel biosensor to study cAMP dynamics in cilia and flagella

A novel biosensor to study cAMP dynamics in cilia and flagella

The cellular messenger cAMP regulates multiple cellular functions, including signaling in cilia and flagella. The cAMP dynamics in these subcellular compartments are ill-defined. We introduce a novel FRET-based cAMP biosensor with nanomolar sensitivity that is out of reach for other sensors. To meas...

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Bibliographic Details
Main Authors: Shatanik Mukherjee, Vera Jansen, Jan F Jikeli, Hussein Hamzeh, Luis Alvarez, Marco Dombrowski, Melanie Balbach, Timo Strünker, Reinhard Seifert, U Benjamin Kaupp, Dagmar Wachten
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
cAMP
ciliary
flagella
FRET
sperm
Online Access:https://elifesciences.org/articles/14052

Internet

https://elifesciences.org/articles/14052

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