Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation

Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation

ABSTRACT The inflammasome is essential for host defense against intracellular bacterial pathogens, including Legionella pneumophila, the causative agent of the severe pneumonia Legionnaires’ disease. Inflammasomes recruit and activate caspases, which promote IL-1 family cytokine release and pyroptos...

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Bibliographic Details
Main Authors: Antonia R. Bass, Marisa S. Egan, Jasmine Alexander-Floyd, Natasha Lopes Fischer, Jessica Doerner, Sunny Shin
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Legionella pneumophila
innate immunity
macrophages
inflammasomes
guanylate-binding proteins
caspase-4
Online Access:https://journals.asm.org/doi/10.1128/mbio.01707-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01707-23

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