HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Abstract Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERINC5 down-regulation activity contributes to HIV-1 s...

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Bibliographic Details
Main Authors: Delon Naicker, Nelson Sonela, Steven W. Jin, Takalani Mulaudzi, Doty Ojwach, Tarylee Reddy, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Retrovirology
Subjects:
HIV-1 Nef
HIV-1 subtype C
SERINC5 down-regulation
Online Access:https://doi.org/10.1186/s12977-023-00618-7

Internet

https://doi.org/10.1186/s12977-023-00618-7

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