HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Abstract Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERINC5 down-regulation activity contributes to HIV-1 s...

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Bibliographic Details
Main Authors:	Delon Naicker, Nelson Sonela, Steven W. Jin, Takalani Mulaudzi, Doty Ojwach, Tarylee Reddy, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Series:	Retrovirology
Subjects:	HIV-1 Nef HIV-1 subtype C SERINC5 down-regulation
Online Access:	https://doi.org/10.1186/s12977-023-00618-7

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