Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice

Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice

The R-spondin (RSPO) family of proteins potentiate canonical WNT/β-catenin signaling and may provide a mechanism to fine-tune the strength of canonical WNT signaling. Although several in vitro studies have clearly demonstrated the potentiation of canonical WNT signaling by RSPOs, whether this potent...

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Bibliographic Details
Main Authors: Yong-Ri Jin, Xiang Hua Han, Katsuhiko Nishimori, Dan Ben-Avraham, Youn Jeong Oh, Jae-won Shim, Jeong Kyo Yoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
R-spondin2
Wnt9b
WNT signaling
facial development
cleft lip
cleft palate
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00264/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00264/full

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