Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm

Abstract A major complication in COVID-19 infection consists in the onset of acute respiratory distress fueled by a dysregulation of the host immune network that leads to a run-away cytokine storm. Here, we present an in silico approach that captures the host immune system’s complex regulatory dynam...

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Bibliographic Details
Main Authors: Spencer Richman, Cole Lyman, Anastasia Nesterova, Anton Yuryev, Matthew Morris, Hongbao Cao, Chris Cheadle, Gary Skuse, Gordon Broderick
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-022-00250-9