Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression‐like behaviors in 5xFAD mice

Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression‐like behaviors in 5xFAD mice

Abstract Background Apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease, and it can aggravate depressive symptoms in non‐AD patients. However, the impact of ApoE4 on AD‐associated depression‐like behaviors and its underlying pathogenic mechan...

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Bibliographic Details
Main Authors: Yanju Gong, Mingfeng Li, Min Liu, Xinghan Wu, Yanhong Li, Chuan Qin, Ling Zhang
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:Animal Models and Experimental Medicine
Subjects:
5xFAD mice
Alzheimer's disease
ApoE4 allele
depression like
Online Access:https://doi.org/10.1002/ame2.12446

Internet

https://doi.org/10.1002/ame2.12446

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