Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

Abstract Background Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-specific antibodies and T-cell checkpoint inhibitors by pro...

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Bibliographic Details
Main Authors: Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Hematology & Oncology
Subjects:
SIRPα
CD47
Macrophage
Phagocytosis
Immunotherapy
Innate immune checkpoint
Online Access:https://doi.org/10.1186/s13045-020-00989-w

Internet

https://doi.org/10.1186/s13045-020-00989-w

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