ERα determines the chemo-resistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions

ERα determines the chemo-resistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions

Mutant p53 (mutp53) commonly loses its DNA binding affinity to p53 response elements (p53REs) and fails to induce apoptosis fully. However, the p53 mutation does not predict chemoresistance in all subtypes of breast cancers, and the critical determinants remain to be identified. In this study, mutp5...

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Bibliographic Details
Main Authors: Yu-Hao He, Ming-Hsin Yeh, Hsiao-Fan Chen, Tsu-Shing Wang, Ruey-Hong Wong, Ya-Ling Wei, Thanh Kieu Huynh, Dai-Wei Hu, Fang-Ju Cheng, Jhen-Yu Chen, Shu-Wei Hu, Chia-Chen Huang, Yeh Chen, Jiaxin Yu, Wei-Chung Cheng, Pei-Chun Shen, Liang-Chih Liu, Chih-Hao Huang, Ya-Jen Chang, Wei-Chien Huang
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
mutant p53
estrogen receptor
lincRNA-p21
DDB2
G-quadruplex
chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001906

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http://www.sciencedirect.com/science/article/pii/S2162253121001906

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