Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells

Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells

Immune evasion is considered one of the modern hallmarks of cancer and is a key element in the pathogenesis of classical Hodgkin Lymphoma (cHL). This haematological cancer achieves effective avoidance of the host’s immune system by overexpressing the PD-L1 and PD-L2 proteins on the surface of the ne...

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Bibliographic Details
Main Authors: Alessandro Cellini, Federico Scarmozzino, Francesco Angotzi, Edoardo Ruggeri, Angelo Paolo Dei Tos, Livio Trentin, Marco Pizzi, Andrea Visentin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
Hodgkin lymphoma
microenvironment
Treg
PD-1
LAG-3
immune checkpoint inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1203470/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1203470/full

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