Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer

Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer

Centrosome amplification (CA) is a common phenomenon in cancer, promotes genomic stability and cancer evolution, and has been reported to promote metastasis. CA promotes a stochastic gain/loss of chromosomes during cell division, known as chromosomal instability (CIN). However, it is unclear whether...

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Bibliographic Details
Main Authors: Ashok Singh, Ryan A. Denu, Serena K. Wolfe, Jamie M. Sperger, Jennifer Schehr, Tessa Witkowsky, Karla Esbona, Richard J. Chappell, Beth A. Weaver, Mark E. Burkard, Joshua M. Lang
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Oncology
Subjects:
breast cancer
centrin
centrosome amplification
CTC
EpCAM
pericentrin
Online Access:https://doi.org/10.1002/1878-0261.12687

Internet

https://doi.org/10.1002/1878-0261.12687

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