Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs

Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by a single GABA receptor (UNC-49/GABAA). Mutati...

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Detalles Bibliográficos
Main Authors: Jian Zhao, Luna Gao, Stephen Nurrish, Joshua M. Kaplan
Formato: Artigo
Idioma:English
Publicado: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124723011737