MiR-526b-3p Attenuates Breast Cancer Stem Cell Properties and Chemoresistance by Targeting HIF-2α/Notch Signaling

MiR-526b-3p Attenuates Breast Cancer Stem Cell Properties and Chemoresistance by Targeting HIF-2α/Notch Signaling

Chemoresistance is a severe clinical challenge in breast cancer. Hypoxia and cancer stem cells (CSCs) contribute to the paclitaxel (PTX) resistance, but the molecular mechanisms are still elusive. MicorRNAs (miRNA) have been considered a promising therapeutic strategy in various cancers. Here, we id...

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Bibliographic Details
Main Authors: Jing-Hua Liu, Wen-Ting Li, Yue Yang, Yan-Bo Qi, Yu Cheng, Jia-Hui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
breast cancer
hypoxia
CSCs
chemoresistance
miR-526b-3p
HIF-2α
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.696269/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.696269/full

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