Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology

Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology

Abstract Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse models of beta-amyloidosis. However, the mechanisms...

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Bibliographic Details
Main Authors: Yee Fun Lee, Alyssa N. Russ, Qiuchen Zhao, Stephen J. Perle, Megi Maci, Morgan R. Miller, Steven S. Hou, Moustafa Algamal, Zhuoyang Zhao, Hanyan Li, Noah Gelwan, Zhe Liu, Stephen N. Gomperts, Alfonso Araque, Elena Galea, Brian J. Bacskai, Ksenia V. Kastanenka
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40402-3

Internet

https://doi.org/10.1038/s41598-023-40402-3

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