Epigallocatechin-3-gallate alleviates trans, trans-2,4-decadienal-induced endothelial pyroptosis and dysfunction by inhibiting NLRP3 inflammasome activation

Epigallocatechin-3-gallate alleviates trans, trans-2,4-decadienal-induced endothelial pyroptosis and dysfunction by inhibiting NLRP3 inflammasome activation

Trans, trans-2,4-decadienal (tt-DDE) is a highly reactive unsaturated aldehyde that widely present in foods. This study aimed to investigate the toxic effects of tt-DDE exposure on human umbilical vein endothelial cells (HUVECs) and the possible protective effects of green tea catechins. tt-DDE expo...

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Bibliographic Details
Main Authors: Yuanyuan Hu, Zhengqi Liu, Xiaoya Tao, Jinjin Li, Zuoxu Hou, Xiaoming Guo, Dayong Zhou, Mingfu Wang, Beiwei Zhu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Journal of Functional Foods
Subjects:
Epigallocatechin-3-gallate
Vascular protective
Trans, trans-2,4-decadienal
Pyroptosis
NLRP3 inflammasome
Endothelial cell
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623000282

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http://www.sciencedirect.com/science/article/pii/S1756464623000282

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