Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus

Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus

Noncompetitive N-methyl-D-aspartate/glutamate receptor (NMDAR) antagonists contribute to the pathophysiology of schizophrenia and mood disorders but improve monoaminergic antidepressant-resistant mood disorder and suicidal ideation. The mechanisms of the double-edged sword clinical action of NMDAR a...

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Bibliographic Details
Main Authors: Motohiro Okada, Kouji Fukuyama
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
N-methyl-D-aspartate
schizophrenia
mood disorder
L-glutamate
GABA
catecholamine
Online Access:https://www.mdpi.com/2218-273X/10/7/990

Internet

https://www.mdpi.com/2218-273X/10/7/990

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