Spectroscopy and calorimetry evidence of binding-induced thermal stabilization of human telomeric G-quadruplex DNA by 1,5-disubstituted morpholino-amido anthraquinone: Molecular basis of anticancer action

Spectroscopy and calorimetry evidence of binding-induced thermal stabilization of human telomeric G-quadruplex DNA by 1,5-disubstituted morpholino-amido anthraquinone: Molecular basis of anticancer action

We report interaction of 1,5-Bis (3-morpholinopropionamido) anthracene-9,10-dione with Human Telomeric G4 DNA sequences, wHTel26 and HTel22 in presence of K+ and Na+ ions, respectively. Surface Plasmon Resonance yields association constant Kb = 1.0–3.8x105 M−1 with HTel22 in K+-rich solution. Signif...

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Bibliographic Details
Main Authors: Anjana Kumari, Kumud Pandav, Anuradha Panwar, Mala Nath, Rama Krishna Peddinti, Ritu Barthwal
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Ligand-Human Telomeric G-quadruplex DNA Interaction
1,5-disubstituted morpholino-amido anthraquinone derivative
Absorption
Fluorescence and Circular Dichroism
Surface Plasmon Resonance
Thermal Melting Profiles
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624000201

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http://www.sciencedirect.com/science/article/pii/S2211715624000201

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