The Clinical Concept of LTDpathy: Is Dysregulated LTD Responsible for Prodromal Cerebellar Symptoms?

The Clinical Concept of LTDpathy: Is Dysregulated LTD Responsible for Prodromal Cerebellar Symptoms?

Long-term depression at parallel fibers-Purkinje cells (PF-PC LTD) is essential for cerebellar motor learning and motor control. Recent progress in ataxiology has identified dysregulation of PF-PC LTD in the pathophysiology of certain types of immune-mediated cerebellar ataxias (IMCAs). Auto-antibod...

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Bibliographic Details
Main Authors: Hiroshi Mitoma, Kazuhiko Yamaguchi, Jerome Honnorat, Mario Manto
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Brain Sciences
Subjects:
cerebellar ataxias
immune-mediated cerebellar ataxias
spinocerebellar ataxia
long-term depression
anti-mGluR antibody
anti-VGCC antibody
Online Access:https://www.mdpi.com/2076-3425/12/3/303

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https://www.mdpi.com/2076-3425/12/3/303

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