A statistical perspective on baseline adjustment in pharmacogenomic genome-wide association studies of quantitative change

Abstract In pharmacogenetic (PGx) studies, drug response phenotypes are often measured in the form of change in a quantitative trait before and after treatment. There is some debate in recent literature regarding baseline adjustment, or inclusion of pre-treatment or baseline value as a covariate, in...

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Bibliographic Details
Main Authors: Hong Zhang, Aparna Chhibber, Peter M. Shaw, Devan V. Mehrotra, Judong Shen
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-022-00303-2