A statistical perspective on baseline adjustment in pharmacogenomic genome-wide association studies of quantitative change
Abstract In pharmacogenetic (PGx) studies, drug response phenotypes are often measured in the form of change in a quantitative trait before and after treatment. There is some debate in recent literature regarding baseline adjustment, or inclusion of pre-treatment or baseline value as a covariate, in...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-06-01
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Series: | npj Genomic Medicine |
Online Access: | https://doi.org/10.1038/s41525-022-00303-2 |