Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway

Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway

Abstract Triple negative breast cancer (TNBC) is associated with worse outcomes and results in high mortality; therefore, great efforts are required to find effective treatment. In the present study, we suggested a novel strategy to treat TNBC using mesenchymal stem cell (MSC)-derived extracellular...

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Bibliographic Details
Main Authors: Yun-Hsuan Chang, Cat-Khanh Vuong, Nhat-Hoang Ngo, Toshiharu Yamashita, Xiucai Ye, Yasunori Futamura, Mizuho Fukushige, Mana Obata-Yasuoka, Hiromi Hamada, Motoo Osaka, Yuji Hiramatsu, Tetsuya Sakurai, Osamu Ohneda
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17767-y

Internet

https://doi.org/10.1038/s41598-022-17767-y

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