Metagenomic sequencing of human cardiac tissue reveals Microbial RNA which correlates with Toll-like receptor-associated inflammation in patients with heart disease

Abstract Cardiovascular disease (CVD) is strongly associated with chronic low-grade inflammation, involving activated Toll-like receptors and their downstream cellular machinery. Moreover, CVD and other related inflammatory conditions are associated with infiltration of bacteria and viruses originat...

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Bibliographic Details
Main Authors: Joakim Sandstedt, Kristina Vukusic, Göran Dellgren, Anders Jeppsson, Lillemor Mattsson Hultén, Victoria Rotter Sopasakis
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35157-w