Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration

Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration

The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure to support tumor growth. Anterior gradient-2 (AGR2), a tumor secretory protein is believed to play a pivotal role during tumor microenvironment (TME) development. Here, we report that extr...

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Bibliographic Details
Main Authors: Hitesh Bhagavanbhai Mangukiya, Hema Negi, Siva Bharath Merugu, Qudsia Sehar, Dhahiri Saidi Mashausi, Fakhar-Un-Nisa Yunus, Zhenghua Wu, Dawei Li
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Cell Adhesion & Migration
Subjects:
anterior gradient 2
rhoa gtp-binding protein
fibroblasts
cell movement
tumour microenvironment
Online Access:http://dx.doi.org/10.1080/19336918.2019.1685928

Internet

http://dx.doi.org/10.1080/19336918.2019.1685928

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