Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?

Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?

Currently, SARS-CoV-2 spike receptor-binding-domain (RBD)-based vaccines are considered one of the most effective weapons against COVID-19. During the first step of assessing vaccine immunogenicity, a mouse model is often used. In this paper, we tested the use of five experimental animals (mice, ham...

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Bibliographic Details
Main Authors: Iuliia A. Merkuleva, Dmitry N. Shcherbakov, Mariya B. Borgoyakova, Anastasiya A. Isaeva, Valentina S. Nesmeyanova, Natalia V. Volkova, Vazirbek S. Aripov, Daniil V. Shanshin, Larisa I. Karpenko, Svetlana V. Belenkaya, Elena I. Kazachinskaia, Ekaterina A. Volosnikova, Tatiana I. Esina, Alexandr A. Sergeev, Kseniia A. Titova, Yulia V. Konyakhina, Anna V. Zaykovskaya, Oleg V. Pyankov, Evgeniia A. Kolosova, Olesya E. Viktorina, Arseniya A. Shelemba, Andrey P. Rudometov, Alexander A. Ilyichev
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
receptor-binding domain
animal models
Online Access:https://www.mdpi.com/1999-4915/14/5/1060

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https://www.mdpi.com/1999-4915/14/5/1060

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