Protection and Safety Evaluation of Live Constructions Derived from the Pgm<sup>−</sup> and pPCP1<sup>−</sup> <i>Yersinia pestis</i> Strain

Based on a live attenuated <i>Yersinia pestis</i> KIM10(pCD1Ap) strain (Pgm<sup>&#8722;</sup>, pPCP1<sup>&#8722;</sup>), we attempted to engineer its lipid A species to achieve improvement of immunogenicity and safety. A mutant strain designated as YPS19(p...

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Bibliographic Details
Main Authors: Xiuran Wang, Amit K. Singh, Wei Sun
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/8/1/95