miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism

miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism

Background/Aims: Increasing evidence shows that reprogramming of energy metabolism is a hallmark of cancer. Considering the emergence of microRNAs as crucial modulators of cancer, this study aimed to better understand the molecular mechanisms of miR-124 in regulating glycolysis in human pancreatic c...

Full description

Bibliographic Details
Main Authors:	De-Hai Wu, Hao Liang, Shou-Nan Lu, Hao Wang, Zhi-Lei Su, Lei Zhang, Jian-Qun Ma, Mian Guo, Sheng Tai, Shan Yu
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:	Cellular Physiology and Biochemistry
Subjects:	microRNA-124 Monocarboxylate transporter 1 Lactate metabolism Pancreatic ductal adenocarcinoma
Online Access:	https://www.karger.com/Article/FullText/494477

Similar Items

Importance of lactate dehydrogenase (LDH) and monocarboxylate transporters (MCTs) in cancer cells
by: Hamed Hatami, et al.
Published: (2023-01-01)

Establishment and validation of a prognostic signature for pancreatic ductal adenocarcinoma based on lactate metabolism-related genes
by: Xin Huang, et al.
Published: (2023-06-01)

Effects of lactate administration on mitochondrial enzyme activity and monocarboxylate transporters in mouse skeletal muscle
by: Kenya Takahashi, et al.
Published: (2019-09-01)

Identification and Validation of Circulating Micrornas as Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma Patients Undergoing Surgical Resection
by: Natalia Gablo, et al.
Published: (2020-07-01)

Identification of Tissue miRNA Signatures for Pancreatic Ductal Adenocarcinoma
by: Carlo Caputo, et al.
Published: (2024-02-01)

Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast
by: Dan Zhao, et al.
Published: (2020-01-01)

Short‐term hypoxic training increases monocarboxylate transporter 4 and phosphofructokinase activity in Thoroughbreds
by: Wenxin Wang, et al.
Published: (2020-06-01)

Structure and function of a monocarboxylate transporter homolog specific for L-lactate
by: Patrick D. Bosshart, et al.
Published: (2019-11-01)

Genome-scale analysis to identify prognostic microRNA biomarkers in patients with early stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy
by: Liao X, et al.
Published: (2018-08-01)

Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma
by: Qingqing Li, et al.
Published: (2019-12-01)

Disparities in Pancreatic Ductal Adenocarcinoma—The Significance of Hispanic Ethnicity, Subgroup Analysis, and Treatment Facility on Clinical Outcomes
by: Andrea N. Riner, et al.
Published: (2020-06-01)

Exploring monocarboxylate transporter inhibition for cancer treatment
by: Tomas Koltai, et al.
Published: (2024-02-01)

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions
by: Christian Prinz, et al.
Published: (2022-08-01)

Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis
by: Bishnupriya Chhatriya, et al.
Published: (2019-12-01)

Clinical Impact of Epithelial-to-Mesenchymal Transition Regulating MicroRNAs in Pancreatic Ductal Adenocarcinoma
by: Sameer Abdallah Dhayat, et al.
Published: (2018-09-01)

Modulation of FoxO1 Expression by miR-21 to Promote Growth of Pancreatic Ductal Adenocarcinoma
by: Weifeng Song, et al.
Published: (2015-01-01)

Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
by: Natalia Michalak, et al.
Published: (2023-06-01)

Surgical Treatment of Pancreatic Ductal Adenocarcinoma
by: Kongyuan Wei, et al.
Published: (2021-04-01)

Oral mycobiota and pancreatic ductal adenocarcinoma
by: Ailin Wei, et al.
Published: (2022-12-01)

Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma
by: Hweixian Leong Penny, et al.
Published: (2021-06-01)

Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma
by: Tomonari Shimagaki, et al.
Published: (2023-11-01)

Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma
by: Dingyuan Hu, et al.
Published: (2019-02-01)

Recent Advances in Pancreatic Ductal Adenocarcinoma: Strategies to Optimise the Perioperative Nutritional Status in Pancreatoduodenectomy Patients
by: James M. Halle-Smith, et al.
Published: (2023-04-01)

Neoadjuvant Treatments for Pancreatic Ductal Adenocarcinoma: Where We Are and Where We Are Going
by: Alessandro Coppola, et al.
Published: (2023-05-01)

Clinically impactful metabolic subtypes of pancreatic ductal adenocarcinoma (PDAC)
by: Jannat Pervin, et al.
Published: (2023-10-01)

Distribution of Monocarboxylate Transporters in Brain and Choroid Plexus Epithelium
by: Masaki Ueno, et al.
Published: (2023-07-01)

Syndecans and Pancreatic Ductal Adenocarcinoma
by: Nausika Betriu, et al.
Published: (2021-02-01)

Microbiome and MicroRNA or Long Non-Coding RNA—Two Modern Approaches to Understanding Pancreatic Ductal Adenocarcinoma
by: Wiktoria Maria Izdebska, et al.
Published: (2023-08-01)

Cancer stem cells and mesenchymal stem cells in pancreatic ductal adenocarcinoma
by: V. O. Tumanskyi, et al.
Published: (2019-06-01)

Novel Treatment Strategies for Advanced Pancreatic Ductal Adenocarcinoma
by: CHENG Yuejuan, et al.
Published: (2022-03-01)

A Simple Model Established by Blood Markers Predicting Overall Survival After Radical Resection of Pancreatic Ductal Adenocarcinoma
by: Li-xiang Zhang, et al.
Published: (2020-04-01)

A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma
by: Chaobin He, et al.
Published: (2019-10-01)

Molecular imaging of pancreatic ductal adenocarcinoma
by: Wei Huang, et al.
Published: (2023-10-01)

Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs
by: Maria Mortoglou, et al.
Published: (2022-03-01)

Potential of Exosomal microRNA-200b as Liquid Biopsy Marker in Pancreatic Ductal Adenocarcinoma
by: Moritz Reese, et al.
Published: (2020-01-01)

Plasminogen Activator Inhibitor 1 as a Poor Prognostic Indicator in Resectable Pancreatic Ductal Adenocarcinoma
by: Wen-Jing Liu, et al.
Published: (2018-01-01)

Role of miR-30a-3p Regulation of Oncogenic Targets in Pancreatic Ductal Adenocarcinoma Pathogenesis
by: Hiroki Shimomura, et al.
Published: (2020-09-01)

An Automated Prognostic Model for Pancreatic Ductal Adenocarcinoma
by: Ioannis Vezakis, et al.
Published: (2023-08-01)

Ferroptosis: New Strategies and Ideas for the Treatment of Pancreatic Ductal Adenocarcinoma
by: Chengru Yang, et al.
Published: (2024-01-01)

Early Recurrence after Upfront Surgery for Pancreatic Ductal Adenocarcinoma
by: Gennaro Nappo, et al.
Published: (2023-03-01)