NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved]
Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues. The dysfunction of NAD+ biosynthesis plays a critical role in the pathophysiologies of multiple...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-02-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/7-132/v1 |
| _version_ | 1819268054848110592 |
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| author | Sean Johnson Shin–ichiro Imai |
| author_facet | Sean Johnson Shin–ichiro Imai |
| author_sort | Sean Johnson |
| collection | DOAJ |
| description | Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues. The dysfunction of NAD+ biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders. As downstream effectors, NAD+-dependent enzymes, such as sirtuins, are involved in the progression of such disorders. These recent studies implicate NAD+ biosynthesis as a potential target for preventing and treating age-associated diseases. Indeed, new studies have demonstrated the therapeutic potential of supplementing NAD+ intermediates, such as nicotinamide mononucleotide and nicotinamide riboside, providing a proof of concept for the development of an effective anti-aging intervention. |
| first_indexed | 2024-12-23T21:26:58Z |
| format | Article |
| id | doaj.art-ab3ae22762754597b04f09a18d6140b2 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-23T21:26:58Z |
| publishDate | 2018-02-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-ab3ae22762754597b04f09a18d6140b22022-12-21T17:30:35ZengF1000 Research LtdF1000Research2046-14022018-02-01710.12688/f1000research.12120.113118NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved]Sean Johnson0Shin–ichiro Imai1Department of Developmental Biology, Washington University School of Medicine, St. Louis, USADepartment of Developmental Biology, Washington University School of Medicine, St. Louis, USANicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues. The dysfunction of NAD+ biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders. As downstream effectors, NAD+-dependent enzymes, such as sirtuins, are involved in the progression of such disorders. These recent studies implicate NAD+ biosynthesis as a potential target for preventing and treating age-associated diseases. Indeed, new studies have demonstrated the therapeutic potential of supplementing NAD+ intermediates, such as nicotinamide mononucleotide and nicotinamide riboside, providing a proof of concept for the development of an effective anti-aging intervention.https://f1000research.com/articles/7-132/v1Small Molecule Chemistry |
| spellingShingle | Sean Johnson Shin–ichiro Imai NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] F1000Research Small Molecule Chemistry |
| title | NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] |
| title_full | NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] |
| title_fullStr | NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] |
| title_full_unstemmed | NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] |
| title_short | NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved] |
| title_sort | nad biosynthesis aging and disease version 1 referees 2 approved |
| topic | Small Molecule Chemistry |
| url | https://f1000research.com/articles/7-132/v1 |
| work_keys_str_mv | AT seanjohnson nadbiosynthesisaginganddiseaseversion1referees2approved AT shinichiroimai nadbiosynthesisaginganddiseaseversion1referees2approved |