Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice

Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice

Activation of T cell responses is essential for effective tumor clearance; however, inducing targeted, potent antigen presentation to stimulate T cell responses remains challenging. We generated Activating Antigen Carriers (AACs) by engineering red blood cells (RBCs) to encapsulate relevant tumor an...

Full description

Bibliographic Details
Main Authors: Katarina Blagovic, Carolyne K. Smith, Amritha Ramakrishnan, Lindsay Moore, David R. Soto, Zachary Thompson, Adam P. Stockmann, Sonia Kruszelnicki, Akshi Thakkar, Jason Murray, Sebastian Torres, Bersabel Wondimagegnhu, Roslyn Yi, Maisam Dadgar, Abdul M. Paracha, Claire Page, Louise Clear, Omer A. Chaudhry, Melissa Myint, Devin T. Bridgen, Jonathan B. Gilbert, Katherine J. Seidl, Armon Sharei, Scott Loughhead, Howard Bernstein, Defne Yarar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
CD8 T cells
dendritic cells
red blood cells
adjuvant
activating antigen carriers
antigen presenting cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1015585/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1015585/full

Similar Items