Genistein Restricts the Epithelial Mesenchymal Transformation (EMT) and Stemness of Hepatocellular Carcinoma via Upregulating miR-1275 to Inhibit the EIF5A2/PI3K/Akt Pathway

Genistein Restricts the Epithelial Mesenchymal Transformation (EMT) and Stemness of Hepatocellular Carcinoma via Upregulating miR-1275 to Inhibit the EIF5A2/PI3K/Akt Pathway

<b>Purpose:</b> Genistein is a natural phytoestrogen with various antitumor effects. In recent years, some microRNAs (miRNA) in cancer cells have been reported to be regulated by genistein. Our study focused on exploring the mechanisms of miRNA upregulation to inhibit the epithelial mese...

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Bibliographic Details
Main Authors: Xiao Yang, Wangjie Jiang, Xiangxu Kong, Xiao Zhou, Deming Zhu, Lianbao Kong
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biology
Subjects:
hepatocellular carcinoma
miR-1275
epithelial mesenchymal transformation
stemness
EIF5A2
Online Access:https://www.mdpi.com/2079-7737/11/10/1383

Internet

https://www.mdpi.com/2079-7737/11/10/1383

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