A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery
Recently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention. Herein, we report a polyvinyl alcohol(PVA)-coated MNs patch with an interconnected porous gel drug reservoir for enhanc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/2/74 |
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| author | Siyuan Chen Takuya Miyazaki Michiko Itoh Hiroko Matsumoto Yuki Moro-oka Miyako Tanaka Yuji Miyahara Takayoshi Suganami Akira Matsumoto |
| author_facet | Siyuan Chen Takuya Miyazaki Michiko Itoh Hiroko Matsumoto Yuki Moro-oka Miyako Tanaka Yuji Miyahara Takayoshi Suganami Akira Matsumoto |
| author_sort | Siyuan Chen |
| collection | DOAJ |
| description | Recently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention. Herein, we report a polyvinyl alcohol(PVA)-coated MNs patch with an interconnected porous gel drug reservoir for enhanced skin penetration efficiency and mechanical strength. The hybrid MNs patch fabricated with a novel, efficient method displayed a “cake-like” two-layer structure, with the tip part being composed of boronate-containing smart gel attached to a porous gel layer as a drug reservoir. The porous structure provides the necessary structural support for skin insertion and space for insulin loading. The mechanical strength of the hybrid MNs patch was further enhanced by surface coating with crystallized PVA. Compared with MNs patches attached to hollow drug reservoirs, this hybrid MNs patch with a porous gel reservoir was shown to be able to penetrate the skin more effectively, and is promising for on-demand, long-acting transdermal insulin delivery with increased patient compliance. |
| first_indexed | 2024-03-09T21:54:01Z |
| format | Article |
| id | doaj.art-ab4389c8296a41d294993d58bce4527a |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T21:54:01Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-ab4389c8296a41d294993d58bce4527a2023-11-23T20:01:17ZengMDPI AGGels2310-28612022-01-01827410.3390/gels8020074A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin DeliverySiyuan Chen0Takuya Miyazaki1Michiko Itoh2Hiroko Matsumoto3Yuki Moro-oka4Miyako Tanaka5Yuji Miyahara6Takayoshi Suganami7Akira Matsumoto8Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, Suqian Advanced Materials Industry Technology Innovation Center, NJTech-BARTY Joint Research Center for Innovative Medical Technology, Nanjing Tech University, Nanjing 212000, ChinaInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, JapanDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, JapanDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, JapanRecently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention. Herein, we report a polyvinyl alcohol(PVA)-coated MNs patch with an interconnected porous gel drug reservoir for enhanced skin penetration efficiency and mechanical strength. The hybrid MNs patch fabricated with a novel, efficient method displayed a “cake-like” two-layer structure, with the tip part being composed of boronate-containing smart gel attached to a porous gel layer as a drug reservoir. The porous structure provides the necessary structural support for skin insertion and space for insulin loading. The mechanical strength of the hybrid MNs patch was further enhanced by surface coating with crystallized PVA. Compared with MNs patches attached to hollow drug reservoirs, this hybrid MNs patch with a porous gel reservoir was shown to be able to penetrate the skin more effectively, and is promising for on-demand, long-acting transdermal insulin delivery with increased patient compliance.https://www.mdpi.com/2310-2861/8/2/74phenylboronic acidgelglucose-responsivemicroneedleinsulindrug reservoir |
| spellingShingle | Siyuan Chen Takuya Miyazaki Michiko Itoh Hiroko Matsumoto Yuki Moro-oka Miyako Tanaka Yuji Miyahara Takayoshi Suganami Akira Matsumoto A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery Gels phenylboronic acid gel glucose-responsive microneedle insulin drug reservoir |
| title | A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery |
| title_full | A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery |
| title_fullStr | A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery |
| title_full_unstemmed | A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery |
| title_short | A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery |
| title_sort | porous reservoir backed boronate gel microneedle for efficient skin penetration and sustained glucose responsive insulin delivery |
| topic | phenylboronic acid gel glucose-responsive microneedle insulin drug reservoir |
| url | https://www.mdpi.com/2310-2861/8/2/74 |
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