PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia

PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia

Abstract The deregulation of BCL2 family proteins plays a crucial role in leukemia development. Therefore, pharmacological inhibition of this family of proteins is becoming a prevalent treatment method. However, due to the emergence of primary and acquired resistance, efficacy is compromised in clin...

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Bibliographic Details
Main Authors: Kinjal Shah, Ahmad Nasimian, Mehreen Ahmed, Lina Al Ashiri, Linn Denison, Wondossen Sime, Katerina Bendak, Iryna Kolosenko, Valentina Siino, Fredrik Levander, Caroline Palm-Apergi, Ramin Massoumi, Richard B. Lock, Julhash U. Kazi
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-023-00914-7

Internet

https://doi.org/10.1038/s41408-023-00914-7

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