Cell stress response impairs de novo NAD+ biosynthesis in the kidney

Cell stress response impairs de novo NAD+ biosynthesis in the kidney

The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD+) production are involved in acute kidney injury (AKI), with a critical role for quinolinate phosphoribosyl transferase (QPRT), a bottleneck enzyme of de novo NAD+ biosynthesis. The molecular mechanisms determining red...

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Bibliographic Details
Main Authors: Yohan Bignon, Anna Rinaldi, Zahia Nadour, Virginie Poindessous, Ivan Nemazanyy, Olivia Lenoir, Baptiste Fohlen, Pierre Weill-Raynal, Alexandre Hertig, Alexandre Karras, Pierre Galichon, Maarten Naesens, Dany Anglicheau, Pietro E. Cippà, Nicolas Pallet
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-01-01
Series:JCI Insight
Subjects:
Metabolism
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.153019

Internet

https://doi.org/10.1172/jci.insight.153019

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