Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

Inhibition of α-glucosidase and α-amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes. Indeno[1,2-b] quinoxalines-carrying thiazole hybrids 1–17 were created and described using NMR. All analogues were tested for...

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Bibliographic Details
Main Authors: Nirvana A. Gohar, Eman A. Fayed, Yousry A. Ammar, Ola A. Abu Ali, Ahmed Ragab, Amal M. Mahfoz, Moustafa S. Abusaif
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
α-Amylase
α-Glucosidase
Fluorinated indeno-quinoxaline
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2367128

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https://www.tandfonline.com/doi/10.1080/14756366.2024.2367128

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