Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats With Puromycin Aminonucleoside Nephrosis

Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats With Puromycin Aminonucleoside Nephrosis

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Clinical evidence indicates that the melanocortin peptide ACTH is effective in inducing remission of nephrotic glomerulopathies like minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), including those resistant to steroids. This suggests that a steroid-independent melancortin...

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Bibliographic Details
Main Authors: Bohan Chen, Zubia Alam, Yan Ge, Lance Dworkin, Rujun Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
glomerular pathobiology
melanocortin 5 receptor
podocytopathy
GSK3β (glycogen synthase kinase 3β)
puromycin aminonucleoside nephrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.887641/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.887641/full

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