[<sup>99m</sup>Tc]Tc-DB1 Mimics with Different-Length PEG Spacers: Preclinical Comparison in GRPR-Positive Models

[<sup>99m</sup>Tc]Tc-DB1 Mimics with Different-Length PEG Spacers: Preclinical Comparison in GRPR-Positive Models

<i>Background</i>: The frequent overexpression of gastrin-releasing peptide receptors (GRPRs) in human cancers provides the rationale for delivering clinically useful radionuclides to tumor sites using peptide carriers. Radiolabeled GRPR antagonists, besides being safer for human use, ha...

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Bibliographic Details
Main Authors: Panagiotis Kanellopoulos, Emmanouil Lymperis, Aikaterini Kaloudi, Marion de Jong, Eric P. Krenning, Berthold A. Nock, Theodosia Maina
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
gastrin-releasing peptide receptor targeting
[<sup>99m</sup>Tc]Tc-radiotracer
tumor targeting
[<sup>99m</sup>Tc]Tc-DB1 mimic
PEG<sub>x</sub>-spacer
neprilysin-inhibition
Online Access:https://www.mdpi.com/1420-3049/25/15/3418

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https://www.mdpi.com/1420-3049/25/15/3418

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