Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1

Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1

Abstract Background The development of multidrug resistance (MDR) associated with the overexpression of the efflux transporters Mdr1 and Cdr1 in Candida species impedes antifungal therapies. The urgent need for novel agents able to inhibit the function of both pumps, led us to evaluate this property...

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Bibliographic Details
Main Authors: Florimar Gil, Jerónimo Laiolo, Brayan Bayona-Pacheco, Richard D. Cannon, Antonio Ferreira-Pereira, María Cecilia Carpinella
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Multidrug resistance
Efflux transporter
Mdr1
Cdr1
Candida albicans
Candida glabrata
Online Access:https://doi.org/10.1186/s12906-022-03745-4

Internet

https://doi.org/10.1186/s12906-022-03745-4

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