Increased Levels of the Parkinson’s Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status

Increased Levels of the Parkinson’s Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status

Autosomal dominant mutations in the gene encoding α-synuclein (<i>SNCA</i>) were the first to be linked with hereditary Parkinson’s disease (PD). Duplication and triplication of <i>SNCA</i> has been observed in PD patients, together with mutations at the N-terminal of the pro...

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Bibliographic Details
Main Authors: Francesca Di Leva, Michele Filosi, Lisa Oyston, Erica Silvestri, Anne Picard, Alexandros A. Lavdas, Evy Lobbestael, Veerle Baekelandt, G. Gregory Neely, Peter P. Pramstaller, Andrew A. Hicks, Corrado Corti
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
A53T
A30P
ITPKB
Parkinson’s disease
PD cortex
Online Access:https://www.mdpi.com/1422-0067/24/3/1984

Internet

https://www.mdpi.com/1422-0067/24/3/1984

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