The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin(hCG)-receptor (LH/hCG-R) (hCG, low-molecular-weight allosteric LH/hCG-R-agonists) can be used to restore them. The aim was to...

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Bibliographic Details
Main Authors: Andrey A. Bakhtyukov, Kira V. Derkach, Viktor N. Sorokoumov, Anna M. Stepochkina, Irina V. Romanova, Irina Yu. Morina, Irina O. Zakharova, Liubov V. Bayunova, Alexander O. Shpakov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
metformin
male reproduction
type 2 diabetes mellitus
allosteric agonist
luteinizing hormone receptor
chorionic gonadotropin
Online Access:https://www.mdpi.com/1422-0067/23/1/198

Internet

https://www.mdpi.com/1422-0067/23/1/198

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